Sensory descriptors which identify neuropathic pain mechanisms in low back pain: a systematic review,

Descriptors provided by patients with neuropathic low back pain (NLBP) with or without spinally referred leg pain are frequently used by clinicians to help to identify the predominant pain mechanisms. Indeed, many neuropathic screening tools are primarily based on subjective descriptors to determine the presence of neuropathic pain. There is a need to systematically review and analyse the existing evidence to determine the validity of such descriptors in this cohort.

Methods: Ten databases were systematically searched. The review adhered to PRISMA and CRD guide- lines and included a risk of bias assessment using QUADAS-2. Studies were included if they contained symptom descriptors from a group of NLBP patients þ/ leg pain. Studies had to include a reference test to identity neuropathic pain from other pain mechanisms.

Results: Eight studies of 3099 NLBP patients were included. Allodynia and numbness were found to discriminate between NLBP and nociceptive LBP in four studies. Autonomic dysfunction, (changes in the colour or appearance of the skin), was also found to discriminate between the groups in two stud- ies. Dysesthesia identified NLBP in 5/7 respectively. Results from studies were equivocal regarding pain described as hot/burning cold and paroxysmal pain in people with NLBP.

Conclusion: Subjectively reported allodynia and numbness would suggest a neuropathic pain mech- anism in LBP. Dysesthesia would raise the suspicion of NLBP. More research is needed to determine if descriptors suggesting autonomic dysfunction can identify NLBP. There is poor consensus on whether other descriptors can identify NLBP.