Disorders of CNS myelination

 

We study glial cell dysfunction in Multiple Sclerosis (MS); a neuroinflammatory condition characterised by demyelination of CNS axons. The ultimate goal is to develop novel pharmacological therapeutics that can enhance remyelination and promote neuronal survival.

Our group also researches the basic processes governing oligodendrocyte myelination of axons during normal postnatal development. By understanding myelination in the absence of CNS damage, we hope that this will aid the discovery of novel methods to enhance remyelination in neuroinflammatory disorders of the adult CNS.

 

 FIGURE 1: Organotypic Cerebellar Slice Culture immunostained for Myelin Basic Protein (Magenta) AND Neurofilament H (Green)