An overarching goal of the the Brighton Neuroimmunology Laboratory is to better understand the important roles of glial cells (astrocytes, microglia & oligodendrocytes) of the central nervous system (CNS) in supporting and promoting neuronal functioning.
We study how glia regulate homeostatic neurotransmission and modulate synaptic plasticity and cognition.
We are also interested in how glial cell dysfunction in neuroinflammatory disease states affects neuronal health and synaptic transmission.
Figure: Hippocampal dentate gyrus immunofluorescently-labelled with propidium iodide (cell nuclei; purple) and polysialylated-neural cell adhesion molecule (PSA-NCAM; green).
The Brighton Neuroimmunology Laboratory is currently engaged in several collaborative and interdisciplinary research projects such as:
- Calcium channels as drug targets for neuroprotection in Multiple Sclerosis
- Mechanobiology of the ageing brain
- How stress affects cognition and memory in old age
- Effects of AMPAkines on glial calcium signalling
- Effects of neuroinflammation on myelination in the Alzheimer’s diseased brain
Figure: Glial calcium imaging.