An overarching goal of the the Brighton Laboratory for Neuroimmunology (BLN) is to better understand the important roles of glial cells (astrocytes, microglia & oligodendrocytes) of the central nervous system (CNS) in supporting and promoting neuronal functioning.
We study how glia regulate homeostatic neurotransmission and modulate synaptic plasticity and cognition.
We are also interested in how glial cell dysfunction in neuroinflammatory disease states affects neuronal health and synaptic transmission.
Figure: Hippocampal dentate gyrus immunofluorescently-labelled with propidium iodide (cell nuclei; purple) and polysialylated-neural cell adhesion molecule (PSA-NCAM; green).
The BLN is currently engaged in several collaborative interdisciplinary research projects including:
- How stress and social isolation affects cognition in old age
- Calcium channels as drug targets for neuroprotection in Multiple Sclerosis
- Mechanobiology of the ageing brain
- Effects of systemic inflammation on brain myelination in Alzheimer’s disease
- Effects of AMPAkines on glial calcium signalling
Figure: Glial calcium imaging.