Does heat acclimation attenuate the physiological and cellular stress response to Hypoxia?

An ECHO grant of £1000 was awarded to Oliver Gibson- PhD student at the School of Sport and Service Management- to facilitate the analysis of genes associated with exercise in both hot conditions and at high altitude.

This allowed Oliver Gibson’s PhD completion with the inclusion of sophisticated measures not possible without grant funding. Additionally the grant, and subsequent advanced analysis would benefit wider members of SaSM demonstrating excellence in the Sport and Exercise Science field.

The 2015 ECHO grant was fundamental in facilitating sophisticated analysis of two genes (Hsp72 and Hsp90α) which are known to respond to exercise in hot conditions, and altitude. The ECHO grant allowed us to identify that, after training for two weeks in hot conditions, the increase in one of the genes (Hsp72) in simulated altitude no longer occurs. This shows that the training in hot conditions allowed the body to adapt sufficiently to be protected against the reduced oxygen of altitude.”

The data which the ECHO grant facilitated allowed for the presentation of this experimental work at the 2015 “School of Sport and Service Management Student Conference” and led to a published research paper.

Further analysis of the gene responses to training has also lead to a further publication  Gibson, O.R., Tuttle, J.A., Watt, P.W., Maxwell, N.S. and Taylor, L (2016) Hsp72, and Hsp90α mRNA transcription is characterised by large, sustained changes in core temperature during heat acclimation. Cell Stress and Chaperones.