Good luck to everyone getting their A-Level results today!
If it doesn’t go to plan or you’ve had a change of heart about what you want do next, Clearing is a chance to change direction and make new plans.
If you need help navigating your way through the Clearing process, check out our handy online guide and see which courses you can still apply for. You can also call our Clearing hotline on 01273 644000 which is open now, and has extended hours from 7am to 7pm on results day.
If you’ve not yet visited the University of Brighton we have Clearing open days on Saturday 17th and Tuesday 20th August. You’ll be able to take a tour of the campus where you will be studying, get advice about accommodation, take part in a Q&A with academic staff and chat to students. Find out more about visiting us.
If you’re navigating big choices and big changes, we say: stay curious, explore, and trust yourself. The best journeys don’t always follow a map.
New research could pave the way to further important breakthroughs in the development of cancer treatments.
The research looked at why a protein that can play a key role in the development of cancer binds with drugs differently, depending on the amount of drug present.
The protein in question, NQO1, is already being investigated as a possible target for new cancer drugs as up to 25 percent of the human population can have too little of it which increases their chances of developing the disease. However, the protein has properties which mean that it binds differently to some anti-cancer drugs and the more of the drug present the less tightly the protein binds to the drug. This is known as ‘negative co-operativity’.
The research showed that this negative co-operativity does not occur if motion within the protein is modulated by altering its sequence. Amazingly, the researchers found that altering just one building block (a glycine amino acid in the middle of the protein) was enough to abolish negative co-operativity. This happens because this tiny change alters the overall ‘wobbliness’ of the protein. The findings could apply to other proteins and potentially lead to improvements in understanding a wide range of diseases.
Speaking about the research, Professor David Timson, Head of the School of Pharmacy and Biomolecular Sciences at the University of Brighton said: “It is already known that the lack of this protein can increase cancer risk. It is now known that this protein exhibits negative co-operativity with some anti-cancer drugs. Our research has now shed new light on why this is the case and established that by altering the ‘wobbliness’ of the protein we can change its properties and encourage it to bind with anti-cancer drugs more effectively.”
The research, which has been published in ChemBioChem, was carried out in collaboration with scientists from Queens University Belfast, Manchester University and Nottingham Trent University and funded by grants from the Medical Research Council and Association for International Cancer Research.
A Brighton scientist who helped develop anti-ageing compounds based on those found in red wine and chocolate is to explain how close we are to alleviating and preventing old age degenerative diseases.
Professor Lizzy Ostler, the University of Brighton’s Professor of Chemical Biology in our school, and a member of the University of Brighton’s Centre for Stress and Age-Related Disease, is giving her inaugural lecture on 20 March.
In her lecture ‘Not aged by time’ Professor Ostler will explain how she has used her “distinctively cynical approach to research, education and curriculum design both to inspire students and to develop novel potential anti-degenerative drugs”. She will also explain how her research demonstrates that the alleviation and prevention of the consequences of ageing have “finally become realistic and achievable goals”.
She said: “We are on the cusp of a real breakthrough.”
In our latest podcast, Lizzy discusses how close we are to alleviating and preventing old age degenerative diseases, as well as her teaching style.
Two University of Brighton scientists are joining a pop-up stand in Brighton’s Churchill Square shopping centre on Friday (1 Feb) as part of events to mark next Monday’s (4 Feb) World Cancer Day.
Marta Falcinelli, PhD researcher in the University’s School of Pharmacy and Biomolecular Sciences (PABS), is passionate about fighting the disease and will be talking to members of the public at the Cancer Research UK (CRUK) event.
Marta joined the University’s Stress & Cancer group in 2016, fulfilling her ambition: “I have always been intrigued by science and at university I started to be very interested in molecular biology and scientific investigation, dreaming to perform experiments and work in a lab.
Final year students from across our Geography, Geology, Environmental Sciences, Civil Engineering, and Chemistry courses took a trip to the beach this week to collect grab samples of bathing water from seven sites between Brighton Palace Pier and Brighton Marina.
The trip was part of a water and health module and was to look at how water quality varies.
The samples were taken back to our Category 2 microbiology lab for analyses which involved the students filtering the samples for different groups of faecal indicator bacteria originating from different source such as wild birds, dogs and humans.
The concentration of these microorganisms gives us an indication of the likely level of risk to water users. The students will collect additional samples and to analyse over the next two weeks so they can see how water quality changes from week to week as well as from site to site.