Novel compounds designed and made by Chemistry@brighton researchers in the news

 

Stilbene synthesisportrait of Dr Lizzy OstlerMany students on the Chemistry and Pharmaceutical and Chemical Sciences courses at Brighton will already be familiar with the exciting world of small molecule therapies designed to slow ageing –through Dr Ostler’s (in)famous CH210 group consultancy report.  The joys and difficulties of sorting anecdotal life extensionist optimisim from genuine scientific discoveries brought to life in this second year assessment gained a new twist this week.

 

portrait of Professor Richard FaragherExciting new research conducted in a collaboration between Dr Ostler, Professor Faragher (also at the University of Brighton) and Prof Lorna Harries at Exeter University was recently published in BMC Cell Biology.

The discovery showed that novel small molecule analogues of the stilbene resveratrol (found naturally in red wine and chocolate) could “rejuvenate” senescent cells.  The treated cells began to grow again and took on many features of “young” cells.  The team also showed that this was because of changes in RNA splicing factors, the cellular machinery that allows cells to make many different kinds of protein from a single DNA sequence.  The ability to use small molecules to intervene in this previously unexplored mechanism provides new possibilities for the development of anti-degenerative compounds that could allow people to remain heathier well into old age.

Earlier this week the mainstream press became interested in these discoveries, leading to some great headlines including the Sun’s “Wine’s end of the lines, Red wine and chocolate are secret to beating wrinkles, study says” and the Daily Mail’s “Chocolate and red wine ‘are the secret to beating wrinkles’: Scientists find both help rejuvenate old cells as well as the less dramatic “Reversing Aging: Scientists Make Old Human Cells Look And Act Younger in Breakthrough Discovery” from Newsweek and “Breakthrough: Scientists reverse aging in human cells” from Medical News Today.  Our thoughts on the subject will be appearing soon in The Conversation.

All of this was made possible by chemistry and biology researchers working together – something we prize in our undergraduate degrees and that is reflected in our multidisciplinary School of Pharmacy and Biomolecular Sciences.  Whatever your conclusions about red wine and chocolate, it is clear that our researchers and students will keep generating much food for thought!

Careers Fair – Wednesday 8th November

The University of Brighton is holding its annual careers fair on wednesday 8th November at the Amex Stadium, Falmer 11 am – 3pm..

Many employers will be there alongside guidance on options for further study and for improving your chances of getting that job.

More information can be found on the university careers fair website, including a full list of exhibitors at the fair.

Of interest to chemists might be BMW, where we have had students attend placements in the last few years, CGG a geosciences company, NHS scientist training, Roche Diagnostics, Southern Water and postgraduate education information (including PGCE).

Do you want to live forever?

Professor Richard Faragher, Professor of Biogerontology here at University of Brighton and based in our School, will be debating whether science should be able to help us live forever (or longer at least). The debate will be streamed live tomorrow, Tuesday 7th November at 7pm (UK time) from the Universty of Santiago de Compostela. It promises to be an entertaining and informative discussion covering everything from the science of ageing to the ethics and social implications surrounding it. You can tune in to the debate live at the Regueifas de Ciencia ’17 website here you can also find out more about the debate itself.Advert for debate

Latest article publications from chemistry staff – October

Update of publications from our chemistry staff and research students

New for 2017/18 a monthly round-up of publications from staff and students in the chemistry area here at Brighton. Suscribe to the blog and get regular updates on what we are doing here at brighton

Dr Ostler and Dr Vishal Birar (ex-PhD student) are co-authors on the open access article “Small molecule modulation of splicing factor expression is associated with rescue from cellular senescence” in BMC Cell Biology.

Dr Cragg, Dr Willows, Dr Patel, Dr Kothur (ex-PhD student) and Ms Kamenica (MPhil student) have authored an open access article “Lithium ion sensors” in the journal Sensors