Anti-depressants could combat infections

Researchers here at the University of Brighton have found drugs used to treat mood disorders are also potentially active against bacteria which cause catheter infections.

The discovery could lead to new methods of treating infections and could contribute to overcoming problems with antibiotic resistance.

The research, led by Dr Brian Jones, Reader in Molecular and Medical Microbiology and Deputy Head of the our School of Pharmacy and Biomolecular Sciences, has been published in the journal Scientific Reports.

Dr Jones and collaborators Dr Mark Sutton from Public Health England and Dr Khondaker Miraz Rhaman from King’s College London have been studying infections associated with the use of urinary catheters which are used in their millions across the world every year. The bacterium Proteus mirabilis often causes catheter infections and forms crystalline biofilms on catheter surfaces that block urine flow and lead to potentially life-threatening complications.

Catheters are widely used for long-term bladder management in both the community and nursing homes but the care of individuals undergoing long-term catheterisation is frequently undermined by infections.

Dr Jones said: “The majority of patients undergoing long-term catheterisation are cared for outside the hospital environment where catheter blockage is often not noticed until more serious complications arise.

“A particular hazard of catheter blockage is the accumulation of infected urine in the bladder, which eventually results in upper urinary tract infection and the onset of potentially fatal complications including septicaemia.

“It has been estimated that 50 per cent of individuals undergoing long-term catheterisation will suffer from catheter blockage at some point during their care, with chronic blockage also a common problem.

“It is perhaps then unsurprising that blockage is also the cause of numerous emergency hospital referrals, and not only damages the health of patients but also places significant strain on healthcare resources.” Continue reading

Breakthrough in ageing research

University of Brighton scientists have helped discover a way of regenerating  ageing skin cells – with compounds based on those found in red wine, dark chocolate and red grapes.

Laboratory experiments showed cells not only look physically younger but behave more like young cells and start dividing.

Professor Richard Faragher, Professor of Biogerontology, and Dr Lizzy Ostler, Head of Chemistry, said the breakthrough should generate more research into tackling health issues associated with ageing.

Professor Faragher said: “These findings illustrate the enormous potential of ageing research to improve the quality of later life. Older people no more want to be sickly ‘frequent flyers’ with the NHS than teenagers do.

“A recent Government report recognised historic underinvestment in ageing research in the UK. I say to politicians of all parties: Redress this now and give our older people the healthy futures they deserve.”

Dr Ostler said: “Breakthroughs of this kind really need chemists and biologists working on research and teaching together under the same roof. We prize our multidisciplinary collaborative atmosphere at Brighton. This breakthrough vindicates that approach.”

The scientists, members of the University’s Stress, Ageing and Disease Centre of Research and Enterprise Excellence, worked together to select the best compounds for testing from a library designed and synthesised by Dr Vishal Birar, whilst he was undertaking a University of Brighton-funded PhD studentship under Dr Ostler’s supervision. Continue reading

Should science help us live forever?

One of the UK’s leading experts on ageing is discussing whether science should help us live forever in a debate being streamed live around the world.

Professor Richard Faragher, Professor of Biogerontology here at Brighton, rejects the idea that the objective of ageing research should be the indefinite extension of human life. He argues: “This focus allows a selfish minority to misrepresent the altruistic goals of the scientific community.”

Professor Faragher is joining other eminent experts in Coruña, Spain for the debate on 7 November.

He believes there should be more investment in researching drugs and treatments to improve the quality of life in older age: “At a time when our capacity to translate new knowledge about the mechanisms of ageing into medicines and lifestyle advice is limited only by a chronic shortage of funds, older people are ill-served by self-indulgent science fiction.

“They need practical action to restore their health and they need it yesterday.”

The Professor’s comments come in the wake of recent discoveries he and his collaborator, Professor Lorna Harries of Exeter University, published recently on a new mechanism controlling ageing which they hope may prove amenable to treatment.

The debate will be conducted in Spanish and English, with simultaneous interpretation to and from each language. It has been organised by the University of Santiago de Compostela and is funded by the Spanish Foundation for Science and Technology of the Spanish Government’s Ministry of Economy and Competitiveness.

To listen to the debate, go to: regueifas.org