A recent study by the team aims to continue to understand the role mucosal serotonin plays within the colon. This current investigation goes in more detail to unravel which muscle tones and signalling mechanism by which mucosal serotonin release occurs.
The study findings showed that serotonin is released by activation of mechanosensitive TRP channels and that at lower concentrations is more associated with longitudinal rather than circular stretch. The study also provide insight that mucosal serotonin plays no role in phasic colonic contractions.
The findings were published in Neurogastroenterology & Motility and the study was titled Mucosal serotonin overflow is associated with colonic stretch rather than phasic contractions