Enteric glia mediate neuron death in colitis through purinergic pathways

A new published study alongside Prof Gulbransen (Michigan State University) study shows that that the activation of glial cells in the context of neuroinflammation kills enteric neurons. Mediators of inflammation that include ATP and NO activate neurotoxic pathways that converge on glial Cx43 hemichannels. The glial response to inflammatory mediators might contribute to the development of motility disorders. The paper is published in Cellular and Molecular Gastroenterology and Hepatology.